Clinical Research

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The University of Nottingham Health Service is an NIHR CRN East Midlands Research Leadership site.

We have over 10 years experience in delivering NHS research, contributing to its future viability and benefiting our patients.

We have a broad portfolio but at the moment we are focused mainly on vaccine and immunity research and studies looking at ways to improve the mental health of younger people.

Priority Covid-19 Vaccine research

Comparing COVID-19 Vaccine Schedule Combinations (Com-COV2) Study

There are now a number of vaccines in the UK that have been approved to prevent COVID-19, and others are expected to be approved in the near future. These use two-doses, a ‘prime’ first dose, followed by a ‘boost’ second dose some weeks later. The purpose of this trial is to see how well people’s immune systems respond when their second “boost” dose is a different type of vaccine to their first “prime” dose. We will also be looking at how common vaccine reactions, such as fever, are after such ‘mixed’ schedules. This is important, as being able to use different vaccines in this way creates a more flexible immunisation programme; potentially allowing more people to be immunised more quickly.

In this study we will be enrolling men and women aged 50 years and over who have already had one dose of a COVID-19 vaccine. We are enrolling from all ethnicities and would particularly welcome participants from the Black, Asian and Minority Ethnic (BAME) community.

For more information and to sign up please visit participate-nottingham-comcov2 | Com-CoV (comcovstudy.org.uk) 

Comparing COVID-19 Vaccine Schedule Combinations (Com-COV) Study

We are recruiting people 50 years of age and over to a study of  ‘mixed’ schedules of different COVID-19 vaccines.

There are now a number of vaccines that have been approved to prevent COVID-19 in the UK. These use two-doses, a ‘prime’ first dose, followed by a ‘boost’ second dose some weeks later. The purpose of this trial is to see how well people’s immune systems respond when they are primed with one type of vaccine, then boosted with another and to see how good the response is when the second dose is separated from the first dose by different periods of time.

COVID-19 vaccine study (COV002)

Working with the University of Oxford and in partnership with the University of Nottingham, Nottingham University Hospitals NHS Trust (NUH) and NIHR CRN East Midlands we are helping to develop a safe vaccine that can be used to create immunity against the pandemic Coronavirus, and thus prevent Covid-19 disease. But we need your help. Click here to find out more.

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