Clinical Research

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The University of Nottingham Health Service is an NIHR CRN East Midlands Research Leadership site.

We have over 10 years experience in delivering NHS research, contributing to its future viability and benefiting our patients.

We have a broad portfolio but at the moment we are focused mainly on vaccine and immunity research and studies looking at ways to improve the mental health of younger people.

Priority Covid-19 Vaccine research

PANORAMIC IS A UK-WIDE CLINICAL STUDY SPONSORED BY THE UNIVERSITY OF OXFORD AND FUNDED BY THE NATIONAL INSTITUTE FOR HEALTH RESEARCH TO FIND OUT IF NEW ANTIVIRAL TREATMENTS FOR COVID-19 IN THE COMMUNITY REDUCE THE NEED FOR HOSPITAL ADMISSION AND HELP PEOPLE TO GET BETTER SOONER.

The University of Nottingham Health Service, Cripps Health Centre is taking part in the national PANORAMIC clinical trial, which aims to find new antiviral treatments for people with COVID-19 that can be taken at home.

To be eligible to join the trial you will need to have a positive test for COVID-19and symptoms that are likely to be caused by COVID-19, starting in the last 5 days.

The trial is open to people aged 50 or over, or 18-49 years with an underlying health condition.

If you are registered and would like more information, please contact us on nnccg.research@nhs.net or 0115 846 8888 and ask for the Research Team. You can join the trial online, even if you are not currently registered with our practice. For full details, visit www.panoramictrial.org

Paused for Recruitment: Comparing COVID-19 Vaccine Schedule Combinations in Adolescents (Com-COV3)

The purpose of this study is to find out how well young people (aged 12-16 years) respond to two doses of COVID-19 vaccine. We will compare three different vaccines at different doses.

We want to find out if giving two doses of different vaccines produces as good an immune response as giving two doses of the same vaccine, in young people.

Find out more and sign up here: https://comcovstudy.org.uk/participate-nottingham-comcov3 

Closed for Recruitment: Comparing COVID-19 Vaccine Schedule Combinations (Com-COV2) Study

There are now a number of vaccines in the UK that have been approved to prevent COVID-19, and others are expected to be approved in the near future. These use two-doses, a ‘prime’ first dose, followed by a ‘boost’ second dose some weeks later. The purpose of this trial is to see how well people’s immune systems respond when their second “boost” dose is a different type of vaccine to their first “prime” dose. We will also be looking at how common vaccine reactions, such as fever, are after such ‘mixed’ schedules. This is important, as being able to use different vaccines in this way creates a more flexible immunisation programme; potentially allowing more people to be immunised more quickly.

In this study we will be enrolling men and women aged 50 years and over who have already had one dose of a COVID-19 vaccine. We are enrolling from all ethnicities and would particularly welcome participants from the Black, Asian and Minority Ethnic (BAME) community.

For more information and to sign up please visit participate-nottingham-comcov2 | Com-CoV (comcovstudy.org.uk) 

Closed for Recruitment:Comparing COVID-19 Vaccine Schedule Combinations (Com-COV) Study

We are recruiting people 50 years of age and over to a study of  ‘mixed’ schedules of different COVID-19 vaccines.

There are now a number of vaccines that have been approved to prevent COVID-19 in the UK. These use two-doses, a ‘prime’ first dose, followed by a ‘boost’ second dose some weeks later. The purpose of this trial is to see how well people’s immune systems respond when they are primed with one type of vaccine, then boosted with another and to see how good the response is when the second dose is separated from the first dose by different periods of time.

Closed for Recruitment: COVID-19 vaccine study (COV002)/COV009

Working with the University of Oxford and in partnership with the University of Nottingham, Nottingham University Hospitals NHS Trust (NUH) and NIHR CRN East Midlands we are helping to develop a safe vaccine that can be used to create immunity against the pandemic Coronavirus, and thus prevent Covid-19 disease. But we need your help. Click here to find out more.

Currently Recruiting Non COVID-19 Research

HIS-UK Condom Study

Evaluating the Home-based Intervention Strategy (HIS-UK) to reduce new Chlamydia infection among young men aged 16-25 years by promoting correct and consistent condom use: What is the cost effectiveness of two different delivery models (face-to-face and digital delivery)? If you have any questions, please contact our research team or visit our study website: www.his-uk.net 

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